Co-Administration of Metformin and N-Acetyl Cysteine Fails to Improve Clinical Manifestations in PCOS Individual Undergoing ICSI

International Journal of Fertility and Sterility

Zahra Ebrahimi¹  Malek Soleimani Mehranjani²  Mohammad Ali Shariatzadeh²  Mohammad Hossein Nasr Esfahani³  Ebrahim Cheraghi⁴ 

[1] 4Obstetrics and Gynecology Unit, Infertility Treatment Center, ACECR, Qom, Iran;DepartmentofBiology, Faculty of Science, Arak University, Arak, Iran;Department ofReproductive Biotechnology at Reproductive Biomedicine Research Center, RoyanInstitute, ACECR, Isfahan, Iran;Medical Sciences Research Laboratory, DepartmentofBiology, Faculty of Science, Arak University,Arak, Iran;

关键词: polycystic ovary syndrome;    metformin;    n;    acetyl cysteine;    insulin resistance;    oxidative stress;   

DOI  :  

来源: DOAJ

【 摘 要 】

BackgroundStudies have demonstrated the efficacy of metformin (MTF ) in reducing insulin resistance and N-acetyl cysteine (NAC) in inhibiting oxidative stress whichare involved in the pathogenesis of polycystic ovarian syndrome (PCOS). We aimed tocompare the effects of MTF and NAC combination on serum metabolite and hormonallevels during the course of ovulation induction in PCOS individual candidates of intracytoplasmic sperm injection (ICSI).Materials and MethodsIn this prospective randomized clinical trial, placebo con-trolled pilot study, 80 patients of polycystic ovarian syndrome at the age of 25-35years were divided into 4 groups (n=20): i. NAC=treated with N-acetyl cysteine(600 mg three times daily), ii. MTF=treated with metformin (500 mg three timesdaily), iii. MTF+NAC=treated with N-acetyl cysteine plus metformin (the offereddoses) and iv. placebo (PLA). A total number of 20 patients (6 from MTF group, 4from NAC group, 6 from MTF+NAC group and 4 from PLA group) were droppedof the study. The drugs were administrated from day 3 of menses of previous cycleuntil ovum pick-up.ResultsSerum levels of luteinizing hormone (LH), total testosterone, cholester-ol and triglyceride, insulin and leptin significantly reduced in the MTF and NACgroups compared to the placebo (p < 0.01). But levels of LH, total testosterone, cholesterol and triglyceride had no significant reduction in the MTF+NAC groups compared to the placebo. The serum levels of malonyldialdehyde (MDA), insulin andleptin reduced significantly after treatment in the MTF+NAC group compared to theplacebo (p < 0.05).ConclusionConsidering the adverse effect of combination therapy, we proposed the conadministration might have no beneficial effect for PCOS patient during course of ovulationinduction of ICSI (Registration Number: IRCT201204159476N1).

【 授权许可】

Unknown