Clinical outcome of various metformin treatments for women with polycystic ovary syndrome

Reproductive medicine and biology

article

Toshiya Matsuzaki¹  Altankhuu Tungalagsuvd¹  Takeshi Iwasa¹  Munkhsaikhan Munkhzaya¹  Kiyohito Yano¹  Yiliyasi Mayila¹  Takako Tokui¹  Rie Yanagihara¹  Sumika Matsui¹  Takeshi Kato¹  Akira Kuwahara¹  Minoru Irahara¹ 

[1] Department of Obstetrics and Gynecology, Graduate School of Biomedical Sciences, Tokushima University

关键词: clomiphene;    metformin;    ovulation induction;    polycystic ovary syndrome;   

DOI  :  10.1002/rmb2.12026

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background : Type 2 Diabetes Mellitus (T2DM) represents one of the most important risk factors for atrial fibrillation (AF). Numerous studies have shown that T2DM and poor glycemic control reflected by glycated hemoglobin A1c (HbA1c) levels are independently associated with new onset AF. Recent experimental studies reported that the increased susceptibility to AF in the diabetic patients was presumably due to the slowing of conduction associated with increased interstitial fibrosis. Systemic inflammation cam play role in the development of atrial fibrillation. High-sensitivity C-reactive protein (hsCRP) is an inflammatory biomarker that independently predicts the cardiovascular risk. This study aimed to determine the association between hsCRP level and glycemic control with total interatrial conduction time in T2DM patients. Subjects and Methods: This was an analytic study with cross-sectional design. A total of samples were 41 patients with T2DM. Peripheral venous blood samples to measure hsCRP and HbA1c were drawn in all study population. The total interatrial conduction time was measured by tissue Doppler echocardiography. Multivariate analysis was performed using multiple regression analysis. P < 0,050 was considered to indicate a statistically significant difference. Results : The high-sensitivity C-reactive protein level was higher in the T2DM patients with HbA1c≥7% than in the T2DM patients with HbA1c<7%, but not statistically significant (0,44±0,30 vs 0,32±0,22; p = 0,183). The total atrial conduction time was longer in the T2DM patients with HbA1c≥7% than in T2DM patients with HbA1c<7%, but not statistically significant (100,29±28,53 vs 94,88±16,50; p = 0,449). Multiple regression analysis showed that hsCRP levels and glycemic control had significant positive correlation with total interatrial conduction time in T2DM patients (r = 0,51; p = 0,004). Conclusions: The hsCRP levels and glycemic control were significant positively correlated with total interatrium conduction time in patients with type 2 diabetes.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND