Alteration in gut microbiota is associated with dysregulation of cytokines and glucocorticoid therapy in systemic lupus erythematosus

Gut Microbes

Kun Chen¹  Chuan Su¹  Qisha Liu¹  Mengchen Guo¹  Yaoyao Zhuang¹  Jianwei Wang¹  Xingyin Liu¹  Zhi Liu¹  Xiaoting Luan¹  Sixie Xu¹  Zhou Dan¹  Yankai Xia²  Kangjian Liu³  Faming Zhang³  Zhenjiang Zech Xu⁴  Yumin Xia⁵  Jingyun Chen⁵  Huixia Wang⁵  Jingang An⁵ 

[1] Department of Pathogen Biology-Microbiology Division, State Key Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, Center for Global Health, Nanjing Medical University;Institute of Toxicology;Medical Center for Digestive Diseases, the second affiliated Hospital of Nanjing Medical University, Key Laboratory of Holistic integrative Enterology, Nanjing Medical University;Nanchang University;Xi’an Jiaotong University;

关键词: systemic lupus erythematosus (sle);    gut microbiota;    cytokines;    glucocorticoid;    autoimmune disease;   

DOI  :  10.1080/19490976.2020.1768644

来源: DOAJ

【 摘 要 】

A growing corpus of evidence implicates the involvement of the commensal microbiota and immune cytokines in the initiation and progression of systemic lupus erythematosus (SLE). Glucocorticoids have been widely used in the treatment of SLE patients, however, glucocorticoid treatment carries a higher risk of other diseases. Using the 16S rRNA technique, we investigated the differences between the gut microbiota associated with the immune cytokines of SLE and relevant glucocorticoid treatment in a female cohort of 20 healthy control subjects (HC), 17 subjects with SLE (SLE-G), and 20 SLE patients having undergone glucocorticoid treatment (SLE+G). We observed that the diversity and structure of the microbial community in SLE+G patients were significantly changed compared to that of SLE-G patients, whereas the gut microbial community of the SLE+G group showed a similarity with the HC group, which implicate that the shift in the gut microbiome could represent a return to homeostasis. Furthermore, the up-regulations of immune cytokines in SLE-G were identified as closely related to gut dysbiosis, which indicates that the overrepresented genera in SLE patients may play roles in regulating expression level of these immune cytokines. This associated analysis of gut microbiota, glucocorticoid therapy, and immune factors might provide novel and insightful clues revealing the pathogenesis of SLE patients.

【 授权许可】

Unknown