Physiology and pathophysiology of cyclooxygenase-2 and prostaglandin E2 in the kidney

Kidney Research and Clinical Practice

Tae-Hwan Kwon¹  Jørgen Frøkiær²  Rikke Nørregaard² 

[1] Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Korea;Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark;

关键词: Acute kidney injury;    Cyclooxygenase;    Obstructive nephropathy;    Prostaglandin E2;    Water balance;   

DOI  :  10.1016/j.krcp.2015.10.004

来源: DOAJ

【 摘 要 】

The cyclooxygenase (COX) enzyme system is the major pathway catalyzing the conversion of arachidonic acid into prostaglandins (PGs). PGs are lipid mediators implicated in a variety of physiological and pathophysiological processes in the kidney, including renal hemodynamics, body water and sodium balance, and the inflammatory injury characteristic in multiple renal diseases. Since the beginning of 1990s, it has been confirmed that COX exists in 2 isoforms, referred to as COX-1 and COX-2. Even though the 2 enzymes are similar in size and structure, COX-1 and COX-2 are regulated by different systems and have different functional roles. This review summarizes the current data on renal expression of the 2 COX isoforms and highlights mainly the role of COX-2 and PGE2 in several physiological and pathophysiological processes in the kidney.

【 授权许可】

Unknown