Metabolite Shifts Induced by Marathon Race Competition Differ between Athletes Based on Level of Fitness and Performance: A Substudy of the Enzy-MagIC Study

Metabolites

Arne Pfeufer¹  DavidC. Nieman²  Jerzy Adamski³  Cornelia Prehn³  Alexander Cecil³  Mark Haid³  Martin Halle⁴  JanaF. Schader⁴  Johannes Scherr⁴  Julia Schoenfeld⁴ 

[1] Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany;North Carolina Research Campus, Appalachian State University, Kannapolis, NC 28081, USA;Research Unit Molecular Endocrinology and Metabolism, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany;School of Medicine, Department of Prevention, Rehabilitation and Sports Medicine, Technical University of Munich, 80992 Munich, Germany;

关键词: metabolism;    biomarker;    exercise;    amino acids;    fatty acids;    urea cycle;   

DOI  :  10.3390/metabo10030087

来源: DOAJ

【 摘 要 】

This study compared metabolite shifts induced by training for, participation in, and recovery from a marathon race competition among athletes divided into three groups based on fitness (relative maximum oxygen uptake (VO₂max)) and performance levels (net running time). Plasma samples from 76 male runners participating in the Munich Marathon were analyzed for metabolite shifts using a targeted metabolomics panel. For the entire cohort of runners, pronounced increases were measured immediately after the race for plasma concentrations of acylcarnitines (AC), the ratio (palmitoylcarnitine + stearoylcarnitine)/free carnitine that is used as a proxy for the activity of the mitochondrial enzyme carnitine palmitoyltransferase, and arginine-related metabolites, with decreases in most amino acids (AA) and phospholipids. Plasma levels of AA and phospholipids were strongly increased 24 and 72 h post-race. Post-race plasma concentrations of AC and arginine-related metabolites were higher in the low compared to top performers, indicating an accumulation of fatty acids and a reliance on protein catabolism to provide energy after the marathon event. This study showed that marathon race competition is associated with an extensive and prolonged perturbation in plasma metabolite concentrations with a strong AC signature that is greater in the slower, less aerobically fit runners. Furthermore, changes in the arginine-related metabolites were observed.

【 授权许可】

Unknown