Linking activation of microglia and peripheral monocytic cells to the pathophysiology of psychiatric disorders

Frontiers in Cellular Neuroscience

Yuta eTakahashi¹  Hiroaki eTomita²  Zhiqian eYu²  Mai eSakai² 

[1] Graduate School of Medicine, Tohoku University;Tohoku University;

关键词: Bipolar Disorder;    Blood-Brain Barrier;    Mental Disorders;    Microglia;    Monocytes;    Schizophrenia;   

DOI  :  10.3389/fncel.2016.00144

来源: DOAJ

【 摘 要 】

A wide variety of studies have identified microglial activations in psychiatric disorders, such as schizophrenia, bipolar disorder, and major depressive disorder. Relatively fewer, but robust, studies have detected activations of peripheral monocytic cells in psychiatric disorders. Considering the origin of microglia, as well as neuropsychoimmune interactions in the context of the pathophysiology of psychiatric disorders, it is reasonable to speculate thatmicroglia interact with peripheral monocytic cells in relevance with the pahogeneses of psychiatric disorders; however, these interactions have drawn little attention. In this review, we summarize findings relevant to activations of microglia and monocytic cells in psychiatric disorders, discuss the potential association between these cell types and disease pathogenesis, and propose perspectives for future research on these processes.

【 授权许可】

Unknown