Pathogenic Factors Correlate With Antimicrobial Resistance Among Clinical Proteus mirabilis Strains

Frontiers in Microbiology

Grzegorz Wróbel¹  Magdalena Chrapek²  Michał Majchrzak³  Aneta Filipiak³  Stanisław Głuszek³  Wioletta Adamus-Białek³  Monika Wawszczak³  Małgorzata Łysek-Gładysińska⁴  Marek Gniadkowski⁵  Elżbieta Literacka⁵ 

[1] Department of Anatomy, Collegium Medicum, Jan Kochanowski University, Kielce, Poland;Department of Mathematics, Jan Kochanowski University, Kielce, Poland;Department of Surgical Medicine with the Laboratory of Medical Genetics, Collegium Medicum, Jan Kochanowski University, Kielce, Poland;Division of Medical Biology, Institute of Biology, Jan Kochanowski University, Kielce, Poland;National Medicines Institute, Warsaw, Poland;

关键词: pathogenic factors;    antimicrobial resistance;    P. mirabilis;    swarming motility;    biofilm;   

DOI  :  10.3389/fmicb.2020.579389

来源: DOAJ

【 摘 要 】

Proteus mirabilis is the third most common etiological factor of urinary tract infection. It produces urease, which contributes to the formation of a crystalline biofilm, considered to be one of the most important virulence factors of P. mirabilis strains, along with their ability to swarm on a solid surface. The aim of this study was to analyze the pathogenic properties of two selected groups of clinical P. mirabilis isolates, antimicrobial susceptible and multidrug resistant (MDR), collected from hospitals in different regions in Poland. The strains were examined based on virulence gene profiles, urease and hemolysin production, biofilm formation, and swarming properties. Additionally, the strains were characterized based on the Dienes test and antibiotic susceptibility patterns. It turned out that the MDR strains exhibited kinship more often than the susceptible ones. The strains which were able to form a stronger biofilm had broader antimicrobial resistance profiles. It was also found that the strongest swarming motility correlated with susceptibility to most antibiotics. The correlations described in this work encourage further investigation of the mechanisms of pathogenicity of P. mirabilis.

【 授权许可】

Unknown