Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12

Brazilian Journal of Medical and Biological Research

关键词: DDX26;    DEAD-box RNA helicase;    7p12;    ribosome biogenesis;   

DOI  :  10.1590/S0100-879X2001001000002

来源: DOAJ

【 摘 要 】

DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension of 8,123 bp of genomic sequence and encodes a transcript of 1.8 kb that is expressed in all tissues evaluated. The predicted amino acid sequence shows a high similarity to a yeast DEAD-box RNA helicase (Dbp9b) involved in ribosome biogenesis. The new helicase maps to 7p12, a region of frequent chromosome amplifications in glioblastomas involving the epidermal growth factor receptor (EGFR) gene. Nevertheless, co-amplification of DDX26 with EGFR was not detected in nine tumors analyzed.

【 授权许可】

Unknown