Brazilian Journal of Medical and Biological Research | |
Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12 | |
A.a. Camargo2  D.n. Nunes2  H.b. Samaia2  L. Liu1  V.p. Collins1  A.j.g. Simpson2  E. Dias-neto2  | |
[1] ,Instituto Ludwig de Pesquisa sobre o CâncerSão Paulo SP ,Brasil | |
关键词: DDX26; DEAD-box RNA helicase; 7p12; ribosome biogenesis; | |
DOI : 10.1590/S0100-879X2001001000002 | |
来源: SciELO | |
【 摘 要 】
DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension of 8,123 bp of genomic sequence and encodes a transcript of 1.8 kb that is expressed in all tissues evaluated. The predicted amino acid sequence shows a high similarity to a yeast DEAD-box RNA helicase (Dbp9b) involved in ribosome biogenesis. The new helicase maps to 7p12, a region of frequent chromosome amplifications in glioblastomas involving the epidermal growth factor receptor (EGFR) gene. Nevertheless, co-amplification of DDX26 with EGFR was not detected in nine tumors analyzed.
【 授权许可】
CC BY
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