Complex Cell Type-Specific Roles of Autophagy in Liver Fibrosis and Cirrhosis

Pathogens

Po-Huang Lee¹  Tzu-Min Hung¹  Chih-Chiang Hsiao¹  Chih-Wen Lin² 

[1] Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan;Division of Gastroenterology and Hepatology, Department of Medicine, E-Da Hospital and I-Shou University, Kaohsiung 824410, Taiwan;

关键词: autophagy;    liver cell;    fibrosis;    cirrhosis;   

DOI  :  10.3390/pathogens9030225

来源: DOAJ

【 摘 要 】

The lysosomal degradation pathway, or autophagy, plays a fundamental role in cellular, tissue, and organismal homeostasis. A correlation between dysregulated autophagy and liver fibrosis (including end-stage disease, cirrhosis) is well-established. However, both the up and downregulation of autophagy have been implicated in fibrogenesis. For example, the inhibition of autophagy in hepatocytes and macrophages can enhance liver fibrosis, whereas autophagic activity in hepatic stellate cells and reactive ductular cells is permissive towards fibrogenesis. In this review, the contributions of specific cell types to liver fibrosis as well as the mechanisms underlying the effects of autophagy are summarized. In view of the functional effects of multiple cell types on the complex process of hepatic fibrogenesis, integrated approaches that consider the role of autophagy in each liver cell type should be a focus of future research.

【 授权许可】

Unknown