Role of Bioactive Compounds in the Regulation of Mitochondrial Dysfunctions in Brain and Age-Related Neurodegenerative Diseases

Cells

Amira Zarrouk¹  Khadidja Kessas²  Omar Kharoubi²  Zhor Chouari²  Taoufik Ghrairi³  Adil El Midaoui⁴  Mohamed Ksila⁵  Imen Ghzaiel⁵  Gérard Lizard⁵ 

[1] Faculty of Medicine, LR12ES05, Lab-NAFS ‘Nutrition—Functional Food & Vascular Health’, University of Monastir, Monastir 5000, Tunisia;Laboratory of Biotoxicology Experimentale, Biodepollution and Phytoremediation, Faculty of Life and Natural Sciences, University Oran1 ABB, Oran 31100, Algeria;Laboratory of Neurophysiology, Cellular Physiopathology and Valorisation of BioMoleecules, LR18ES03, Department of Biologie, Faculty of Sciences, University Tunis-El Manar, Tunis 2092, Tunisia;Research Team “Biology: Environment and Health”, Department of Biology, Faculty of Sciences and Techniques Errachidia, Moulay Ismail University of Meknes, Errachidia 52000, Morocco;Team ‘Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA7270/Inserm, University Bourgogne Franche-Comté, 21000 Dijon, France;

关键词: antioxidant therapy;    ageing;    energy metabolism;    mitochondria;    neurodegenerative diseases;   

DOI  :  10.3390/cells11020257

来源: DOAJ

【 摘 要 】

Mitochondria are multifunctional organelles that participate in a wide range of metabolic processes, including energy production and biomolecule synthesis. The morphology and distribution of intracellular mitochondria change dynamically, reflecting a cell’s metabolic activity. Oxidative stress is defined as a mismatch between the body’s ability to neutralise and eliminate reactive oxygen and nitrogen species (ROS and RNS). A determination of mitochondria failure in increasing oxidative stress, as well as its implications in neurodegenerative illnesses and apoptosis, is a significant developmental process of focus in this review. The neuroprotective effects of bioactive compounds linked to neuronal regulation, as well as related neuronal development abnormalities, will be investigated. In conclusion, the study of secondary components and the use of mitochondrial features in the analysis of various neurodevelopmental diseases has enabled the development of a new class of mitochondrial-targeted pharmaceuticals capable of alleviating neurodegenerative disease states and enabling longevity and healthy ageing for the vast majority of people.

【 授权许可】

Unknown