HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) versus adult T-cell leukemia/lymphoma (ATLL)

BMC Research Notes

Sahar Yaslianifard¹  Shiva Bayat²  Sayed-Hamidreza Mozhgani³  Somayeh Yaslianifard³  Reza Faraji³  Majid Teymoori-Rad⁴  Mehdi Norouzi⁴  Mohadeseh Zarei-Ghobadi⁴  Mohsen Sheikhi⁴  Mohammad Farahmand⁴  Mohieddin Jafari⁵ 

[1] Department of Biochemistry, Faculty of Life Sciences of Islamic, Azad University;Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences;Department of Microbiology, School of Medicine, Alborz University of Medical Sciences;Institute of Biochemistry and Biophysics, University of Tehran;Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki;

关键词: Human T-lymphotropic virus type 1;    HTLV-1 associated myelopathy/tropical spastic paraparesis;    Adult T-cell leukemia/lymphoma;    Pathogenesis;    Systems virology;   

DOI  :  10.1186/s13104-021-05521-y

来源: DOAJ

【 摘 要 】

Abstract Objectives Human T cell leukemia virus-1 (HTLV-1) infection may lead to one or both diseases including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) or adult T cell leukemia lymphoma (ATLL). The complete interactions of the virus with host cells in both diseases is yet to be determined. This study aims to construct an interaction network for distinct signaling pathways in these diseases based on finding differentially expressed genes (DEGs) between HAM/TSP and ATLL. Results We identified 57 hub genes with higher criteria scores in the primary protein–protein interaction network (PPIN). The ontology-based enrichment analysis revealed following important terms: positive regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle and positive regulation of transcription from RNA polymerase II promoter by histone modification. The upregulated genes TNF, PIK3R1, HGF, NFKBIA, CTNNB1, ESR1, SMAD2, PPARG and downregulated genes VEGFA, TLR2, STAT3, TLR4, TP53, CHUK, SERPINE1, CREB1 and BRCA1 were commonly observed in all the three enriched terms in HAM/TSP vs. ATLL. The constructed interaction network was then visualized inside a mirrored map of signaling pathways for ATLL and HAM/TSP, so that the functions of hub genes were specified in both diseases.

【 授权许可】

Unknown