Multispectral optoacoustic tomography for non-invasive disease phenotyping in pediatric spinal muscular atrophy patients

Photoacoustics

Joachim Woelfle¹  Regina Trollmann²  Andreas Roos³  Adrian Buehler⁴  Adrian P. Regensburger⁴  Vera Danko⁴  Maximilian J. Waldner⁴  Alexandra L. Wagner⁴  Jörg Jüngert⁴  Stephanie Schuessler⁴  Ferdinand Knieling⁴  Hanns Lochmüller⁵  Anna Federle⁶  Markus F. Neurath⁶  Daniel Klett⁶ 

[1] Brain and Mind Research Institute, University of Ottawa, Ottawa, Canada;Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Canada;Department of Pediatric Neurology, Developmental Neurology and Social Pediatrics, University of Duisburg-Essen, Essen, Germany;Department of Pediatrics and Adolescent Medicine, Friedrich-Alexander-University (FAU) Erlangen-Nuremberg, Erlangen, Germany;Division of Neurology, Department of Medicine, The Ottawa Hospital, Canada;Medical Department 1, Friedrich-Alexander-University (FAU) Erlangen-Nuremberg, Erlangen, Germany;

关键词: Optoacoustics;    Photoacoustics;    Multispectral optoacoustic tomography;    Spinal muscular atrophie;   

DOI  :  

来源: DOAJ

【 摘 要 】

Proximal spinal muscular atrophy (SMA) is a rare progressive, life limiting genetic motor neuron disease. While promising causal therapies are available, meaningful prognostic biomarkers for therapeutic monitoring are missing. We demonstrate handheld Multispectral Optoacoustic Tomography (MSOT) as a novel non-invasive imaging approach to visualize and quantify muscle wasting in pediatric SMA. While MSOT signals were distributed homogeneously in muscles of healthy volunteers (HVs), SMA patients showed moth-eaten optoacoustic signal patterns. Further signal quantification revealed greatest differences between groups at the isosbestic point for hemoglobin (SWL 800 nm). The SWL 800 nm signal intensities further correlated with clinical phenotype tested by standard motor outcome measures. Therefore, handheld MSOT could enable non-invasive assessment of disease burden in SMA patients.

【 授权许可】

Unknown