Young adult born neurons enhance hippocampal dependent performance via influences on bilateral networks

eLife

Lara M Rangel¹  Hua-an Tseng²  Xue Han²  Ali I Mohammed²  Jia-Min Zhuo²  Mark E Bucklin²  Edward S Boyden³  Mitul Desai³  Howard J Gritton³  Nick TM Robinson⁴  Alan P Jasanoff⁴ 

[1] Media Lab, Massachusetts Institute of Technology, Cambridge, United States;Biomedical Engineering Department, Boston University, Boston, United States;Department of Bioengineering, McGovern Institute, Cambridge, United States;Department of Psychology, Boston University, Boston, United States;

关键词: pattern separation;    spatial learning;    adult born dentate granule cells;    neurogenesis;    optogenetics;    fMRI;   

DOI  :  10.7554/eLife.22429

来源: DOAJ

【 摘 要 】

Adult neurogenesis supports performance in many hippocampal dependent tasks. Considering the small number of adult-born neurons generated at any given time, it is surprising that this sparse population of cells can substantially influence behavior. Recent studies have demonstrated that heightened excitability and plasticity may be critical for the contribution of young adult-born cells for certain tasks. What is not well understood is how these unique biophysical and synaptic properties may translate to networks that support behavioral function. Here we employed a location discrimination task in mice while using optogenetics to transiently silence adult-born neurons at different ages. We discovered that adult-born neurons promote location discrimination during early stages of development but only if they undergo maturation during task acquisition. Silencing of young adult-born neurons also produced changes extending to the contralateral hippocampus, detectable by both electrophysiology and fMRI measurements, suggesting young neurons may modulate location discrimination through influences on bilateral hippocampal networks.

【 授权许可】

Unknown