Effects of nicotine administration on amyloid precursor protein metabolism, neural cell genesis and acquisition of spatial memory

Malta medical journal

Charles Scerri¹ 

关键词: nicotine;    amyloid precursor protein;    neurogenesis;    spatial learning;    hippocampus;   

DOI  :  

学科分类：医学（综合）

来源: University of Malta * Medical School

【 摘 要 】

Nicotine is reported to improve learning and memory in experimental animals. Improved learning and memory has also been related to increased neural cell genesis in the dentate gyrus of the brain hippocampal formation. Stimulation of acetylcholine receptors has also been found to enhance the expression and secretion of amyloid precursor protein (APP) in various cell lines. Aberrent metabolism of APP generates amyloid-beta (Abeta) peptide which is the major pathological lesion found in the brains of Alzheimer’s disease (AD) patients. This paper will focus on the the results obtained in our laboratory on the effects of acute and chronic nicotine administration on the metabolism of APP, its role in spatial learning and neural cell genesis in the rat brain.

【 授权许可】

Unknown