Nanocomposites for X-ray Photodynamic Therapy

International Journal of Molecular Sciences

Peter Zolotukhin¹  Oleg Kit²  Alexander Soldatov³  Zaira Gadzhimagomedova³  Daria Kirsanova³ 

[1] Academy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don 344090, Russia;Department of Oncology, National Medical Research Centre for Oncology, Rostov-on-Don 344037, Russia;The Smart Materials Research Institute, Southern Federal University, Rostov-on-Don 344090, Russia;

关键词: X-ray photodynamic therapy;    photodynamic therapy;    photosensitizer;    scintillating nanoparticle;    reactive oxygen speeches;    cancer;   

DOI  :  10.3390/ijms21114004

来源: DOAJ

【 摘 要 】

Photodynamic therapy (PDT) has long been known as an effective method for treating surface cancer tissues. Although this technique is widely used in modern medicine, some novel approaches for deep lying tumors have to be developed. Recently, deeper penetration of X-rays into tissues has been implemented, which is now known as X-ray photodynamic therapy (XPDT). The two methods differ in the photon energy used, thus requiring the use of different types of scintillating nanoparticles. These nanoparticles are known to convert the incident energy into the activation energy of a photosensitizer, which leads to the generation of reactive oxygen species. Since not all photosensitizers are found to be suitable for the currently used scintillating nanoparticles, it is necessary to find the most effective biocompatible combination of these two agents. The most successful combinations of nanoparticles for XPDT are presented. Nanomaterials such as metal–organic frameworks having properties of photosensitizers and scintillation nanoparticles are reported to have been used as XPDT agents. The role of metal–organic frameworks for applying XPDT as well as the mechanism underlying the generation of reactive oxygen species are discussed.

【 授权许可】

Unknown