Macrophage Migration Inhibitory Factor (MIF) as a Stress Molecule in Renal Inflammation

International Journal of Molecular Sciences

Hui-Yao Lan¹  Yao-Zhong Kong²  Qiyan Chen² 

[1] Department of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China;Nephrology Department, The First People’s Hospital of Foshan, Foshan 528000, China;

关键词: MIF;    inflammation;    macrophages;    T cells;    kidney diseases;   

DOI  :  10.3390/ijms23094908

来源: DOAJ

【 摘 要 】

Renal inflammation is an initial pathological process during progressive renal injury regardless of the initial cause. Macrophage migration inhibitory factor (MIF) is a truly proinflammatory stress mediator that is highly expressed in a variety of both inflammatory cells and intrinsic kidney cells. MIF is released from the diseased kidney immediately upon stimulation to trigger renal inflammation by activating macrophages and T cells, and promoting the production of proinflammatory cytokines, chemokines, and stress molecules via signaling pathways involving the CD74/CD44 and chemokine receptors CXCR2, CXCR4, and CXCR7 signaling. In addition, MIF can function as a stress molecule to counter-regulate the immunosuppressive effect of glucocorticoid in renal inflammation. Given the critical position of MIF in the upstream inflammatory cascade, this review focuses on the regulatory role and molecular mechanisms of MIF in kidney diseases. The therapeutic potential of targeting MIF signaling to treat kidney diseases is also discussed.

【 授权许可】

Unknown