Leukocyte function in the aging immune system

Journal of Leukocyte Biology

Anjali Desai¹  Raymond Yung²  Annabelle Grolleau-Julius¹ 

[1] Divisions of Geriatric Medicine and Rheumatology, Department of Internal Medicine, University of Michigan, and Divisions of Geriatric Medicine and Rheumatology, Department of Internal Medicine, University of Michigan, and Divisions of Geriatric Medicine and Rheumatology, Department of Internal Medicine, University of Michigan, and;Divisions of Geriatric Medicine and Rheumatology, Department of Internal Medicine, University of Michigan, and Geriatric Research Education and Clinical Center, Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan, USA Divisions of Geriatric Medicine and Rheumatology, Department of Internal Medicine, University of Michigan, and Divisions of Geriatric Medicine and Rheumatology, Department of Internal Medicine, University of Michigan, and Geriatric Research Education and Clinical Center, Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan, USA Geriatric Research Education and Clinical Center, Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan, USA Divisions of Geriatric Medicine and Rheumatology, Department of Internal Medicine, University of Michigan, and Geriatric Research Education and Clinical Center, Ann Arbor Veterans Affairs Health System, Ann Arbor, Michigan, USA

关键词: dendritic cells;    monocytes;    macrophages;    T cells;   

DOI  :  10.1189/jlb.0809542

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Aging is associated with a progressive dysregulation of immune responses. Whether these changes are solely responsible for the observed increased mortality and morbidity amongst the elderly is uncertain. Recent advances have highlighted the age-associated changes that occur beyond T and B lymphocytes. Additionally, multiple human and animal studies have identified a relationship between chronic low-grade inflammation and geriatric syndromes, such as frailty, suggesting that the phenomenon of “inflamm-aging” may provide a rationale for the increased vulnerability to chronic inflammatory diseases in older adults. In the present review, we broadly summarize our current understanding of age-dependent changes in leukocyte function and their contribution to aging-related disease processes.

【 授权许可】

Unknown