期刊论文详细信息
| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Leukocyte function in the aging immune system | |
| 关键词: dendritic cells; monocytes; macrophages; T cells; | |
| DOI : 10.1189/jlb.0809542 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Agingisassociatedwithaprogressivedysregulationofimmuneresponses.Whetherthesechangesaresolelyresponsiblefortheobservedincreasedmortalityandmorbidityamongsttheelderlyisuncertain.Recentadvanceshavehighlightedtheage‐associatedchangesthatoccurbeyondTandBlymphocytes.Additionally,multiplehumanandanimalstudieshaveidentifiedarelationshipbetweenchroniclow‐gradeinflammationandgeriatricsyndromes,suchasfrailty,suggestingthatthephenomenonof“inflamm‐aging”mayprovidearationalefortheincreasedvulnerabilitytochronicinflammatorydiseasesinolderadults.Inthepresentreview,webroadlysummarizeourcurrentunderstandingofage‐dependentchangesinleukocytefunctionandtheircontributiontoaging‐relateddiseaseprocesses...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904049351128ZK.pdf | 174KB |  download |
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