Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium

Nutrients

Rossella Bonzi¹  Carlo La Vecchia¹  Michela Dalmartello¹  Claudio Pelucchi¹  Maria Paula Curado²  Nuria Aragonés³  Jesus Vioque³  Manoli Garcia de la Hera³  Raúl Ulises Hernández-Ramírez⁴  Zuo-Feng Zhang⁵  Giulia Collatuzzo⁶  Eva Negri⁶  Federica Teglia⁶  Paolo Boffetta⁶  Shailja Shah⁷  Reza Malekzadeh⁸  Mohammadreza Pakseresht⁸  Linda M. Liao⁹  M. Constanza Camargo⁹  Charles S. Rabkin⁹  Mary H. Ward⁹  Rashmi Sinha⁹  Nuno Lunet^1,10  Samantha Morais^1,10  Akihisa Hidaka^1,11  Shoichiro Tsugane^1,11  Malaquias López-Cervantes^1,12  Nadia Zubair^1,13  Lizbeth López-Carrillo^1,14  Victor Moreno^1,15 

[1] Branch of Medical Statistics, Biometry, and Epidemiology “G. A. Maccacaro”, Department of Clinical Sciences and Community Health, University of Milan, 20133 Milan, Italy;Centro Internacional de Pesquisa, A. C. Camargo Cancer Center, São Paulo 01508-010, Brazil;Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain;Department of Biostatistics, Yale School of Public Health, New Haven, CT 06520, USA;Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095, USA;Department of Medical and Surgical Sciences, University of Bologna, 40138 Bologna, Italy;Department of Medicine, University of California San Diego, San Diego, CA 92093, USA;Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran P.O. Box 1411713135, Iran;Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892, USA;EPIUnit—Instituto de Saúde Pública, Universidade do Porto, 4050-600 Porto, Portugal;Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo 104-0045, Japan;Facultad de Medicina, National Autonomous University of Mexico (UNAM), Coyoacán 04510, Mexico;Icahn School of Medicine at Mount Sinai, New York, NY 10003, USA;Mexico National Institute of Public Health, Cuernavaca 62100, Mexico;Oncology Data Analytics Program, Unit of Biomarkers and Susceptibility, Catalan Institute of Oncology (ICO), Hospital Duran I Reynals, 08907 Barcelona, Spain;

关键词: gastric cancer;    iron;    diet;    cancer subtypes;    cancer subsites;   

DOI  :  10.3390/nu14122555

来源: DOAJ

【 摘 要 】

Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 case-control studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food frequency questionnaires combined with national nutritional tables. We derived the odds ratios (ORs) and 95% confidence intervals (CIs) for quartiles of dietary iron through multivariable unconditional logistic regression models. Secondary analyses stratified by sex, smoking status, caloric intake, anatomical subsite and histological type were performed. Results: Among 4658 cases and 12247 controls, dietary iron intake was inversely associated with GC (per quartile OR 0.88; 95% CI: 0.83–0.93). Results were similar between cardia (OR = 0.85, 95% CI = 0.77–0.94) and non-cardia GC (OR = 0.87, 95% CI = 0.81–0.94), and for diffuse (OR = 0.79, 95% CI = 0.69–0.89) and intestinal type (OR = 0.88, 95% CI = 0.79–0.98). Iron intake exerted an independent effect from that of smoking and salt intake. Additional adjustment by meat and fruit/vegetable intake did not alter the results. Conclusions: Dietary iron is inversely related to GC, with no difference by subsite or histological type. While the results should be interpreted with caution, they provide evidence against a direct effect of iron in gastric carcinogenesis.

【 授权许可】

Unknown