It Is High Time Physicians Thought of Natural Products for Alleviating NAFLD. Is There Sufficient Evidence to Use Them?

International Journal of Molecular Sciences

Giovanni Tarantino¹  Clara Balsano²  Silvano Junior Santini²  Gaia Sinatti²  Benedetta Cosimini²  Giovanni Brienza²  Irma Clemente² 

[1] Department of Clinical Medicine and Surgery, Federico II University Medical School of Naples, 80100 Naples, Italy;MESVA Department, University of L’Aquila, Piazzale Salvatore Tommasi 1, 67100 L’Aquila, Italy;

关键词: natural products;    nutraceutics;    NAFLD;    animal models;    RCTs;   

DOI  :  10.3390/ijms222413424

来源: DOAJ

【 摘 要 】

Non-alcoholic fatty liver disease (NAFLD) is the most common form of liver disease all over the world due to the obesity pandemic; currently, therapeutic options for NAFLD are scarce, except for diet recommendations and physical activity. NAFLD is characterized by excessive accumulation of fat deposits (>5%) in the liver with subsequent inflammation and fibrosis. Studies in the literature show that insulin resistance (IR) may be considered as the key mechanism in the onset and progression of NAFLD. Recently, using natural products as an alternative approach in the treatment of NAFLD has drawn growing attention among physicians. In this review, the authors present the most recent randomized controlled trials (RCTs) and lines of evidence from animal models about the efficacy of nutraceutics in alleviating NAFLD. Among the most studied substances in the literature, the following molecules were chosen because of their presence in the literature of both clinical and preclinical studies: spirulina, oleuropein, garlic, berberine, resveratrol, curcumin, ginseng, glycyrrhizin, coffee, cocoa powder, epigallocatechin-3-gallate, and bromelain.

【 授权许可】

Unknown