期刊论文详细信息
Frontiers in Neurology
Prevalence and Risk Factors for Unruptured Intracranial Aneurysms in the Population at High Risk for Aneurysm in the Rural Areas of Tianjin
Xinyu Yang1  Xuan Zou1  Jidong Li2  Jie Liu2  Yan Zhao3  Zhangning Jin5  Jinghua Wang5  Jun Tu7  Xianjia Ning8 
[1] Evidence-Based Medicine, Tianjin Jizhou People's Hospital, Tianjin, China;;Center of Clinical Epidemiology &Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China;Department of Neurosurgery, Tianjin Jizhou People's Hospital, Tianjin, China;Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China;Department of Neurosurgery, Tianjin Xiqing Hospital, Tianjin, China;Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous System, Ministry of Education, Tianjin Neurological Institute, Tianjin, China;Laboratory of Epidemiology, Tianjin Neurological Institute, Tianjin, China;
关键词: unruptured intracranial aneurysms;    cervical computed tomography angiography;    epidemiology;    family history;    body mass index;   
DOI  :  10.3389/fneur.2022.853054
来源: DOAJ
【 摘 要 】

Although the prevalence of unruptured intracranial aneurysm (UIA) lies between 2 and 5%, the consequences of aneurysm rupture are fatal. The burden of UIA is considerable in stroke patients. However, the best prevention and management strategy for UIA is uncertain among patients with a family history of stroke. Therefore, this study aimed to determine the epidemiological characteristics and risk factors for UIA based on a population with a family history of stroke. This study used random sampling to recruit participants with a family history of stroke among rural residents in Jixian, Tianjin, China. All participants underwent a questionnaire survey, physical examination, and cervical computed tomography angiography (CTA). CTA data were used to determine whether the subjects had UIA. The relationship between relevant factors and UIA was assessed using logistic regression analysis. A total of 281 residents were recruited in this study, with a mean age of 50.9 years. The prevalence of UIA in those with a family history of stroke was 10.3% overall (9.8% among men and 10.9% among women). Moreover, with each unit increase in body mass index (BMI), the prevalence of UIA decreased by 12.5%. Particularly among non-obese men, BMI had a stronger protective effect (OR: 0.672; 95%CI: 0.499–0.906; P = 0.009), and among non-obese men, an increase in low-density lipoprotein (LDL) was associated with an increased prevalence of UIA (OR: 3.638; 95%CI: 1.108–11.947; P = 0.033). Among the non-obese with a family history of stroke, BMI may be protective against UIA, especially in men. It is crucial to strictly control the LDL level in non-obese people to reduce the burden of UIA.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次