The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders

Frontiers in Endocrinology

Poupak Fallahi¹  Alessandro Antonelli¹  Francesco Ferro²  Marta Mosca²  Chiara Baldini² 

[1] Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy;Rheumatology Unit, University of Pisa, Pisa, Italy;

关键词: Sjögren’s syndrome;    autoimmune thyroid diseases;    non-Hodgkin’s lymphoma;    comorbidities;    pathogenesis;   

DOI  :  10.3389/fendo.2018.00121

来源: DOAJ

【 摘 要 】

Sjögren’s syndrome (SS) and autoimmune thyroid diseases (AITD) may frequently coexist in clinical practice, resulting in a complex overlapping disorder that represents a particular example of the expression of heterogeneity in patients with autoimmune disorders. Objective of this review was to describe the prevalence of the SS–AITD association in the most recent literature, exploring in particular to what extent the presence of AITD might influence the clinical expression of SS and vice versa. Moreover, we summarized some of the proposed genetic, biologic, and molecular mechanisms implied in the pathogenesis of AITD–SS association. Finally, we explored risk factors for lymphoma development in both AITD and SS. We performed a Medline search of English language articles published in the PubMed database in order to provide a critical overview of the recent literature on pathogenesis and clinical features of AITD–SS overlapping disease. All the articles were critically analyzed to select the most relevant contributions.

【 授权许可】

Unknown