Three-Dimensional Porous Scaffolds Derived from Bovine Cancellous Bone Matrix Promote Osteoinduction, Osteoconduction, and Osteogenesis

Polymers

Mathieu Hautefeuille¹  Edgar Jimenez-Díaz¹  Gabriela Piñón-Zarate²  Andrés Castell-Rodríguez²  Alda Malagón-Escandón²  Nadia Vazquez²  Isidro Badillo-Ramírez³  José Manuel Saniger³  Jesus Arenas-Alatorre⁴ 

[1] Facultad de Ciencias, UNAM, Mexico City C.P. 04510, Mexico;Facultad de Medicina, UNAM, Mexico City C.P. 04510, Mexico;Instituto de Ciencias Aplicadas y Tecnología (ICAT), UNAM, Mexico City C.P. 04510, Mexico;Instituto de Física, UNAM, Mexico City C.P. 04510, Mexico;

关键词: three-dimensional porous scaffolds;    bone extracellular matrix;    bone regeneration;    tissue engineering;    biomaterials;   

DOI  :  10.3390/polym13244390

来源: DOAJ

【 摘 要 】

The use of three-dimensional porous scaffolds derived from decellularized extracellular matrix (ECM) is increasing for functional repair and regeneration of injured bone tissue. Because these scaffolds retain their native structures and bioactive molecules, in addition to showing low immunogenicity and good biodegradability, they can promote tissue repair and regeneration. Nonetheless, imitating these features in synthetic materials represents a challenging task. Furthermore, due to the complexity of bone tissue, different processes are necessary to maintain these characteristics. We present a novel approach using decellularized ECM material derived from bovine cancellous bone by demineralization, decellularization, and hydrolysis of collagen to obtain a three-dimensional porous scaffold. This study demonstrates that the three-dimensional porous scaffold obtained from bovine bone retained its osteoconductive and osteoinductive properties and presented osteogenic potential when seeded with human Wharton’s jelly mesenchymal stromal cells (hWJ-MSCs). Based on its characteristics, the scaffold described in this work potentially represents a therapeutic strategy for bone repair.

【 授权许可】

Unknown