Polymer Scaffolds for Biomedical Applications in Peripheral Nerve Reconstruction

Molecules

Li-Ping Zhou¹  Meng Zhang²  Ci Li²  Wei Pi²  Pei-Xun Zhang² 

[1] Beijing Key Laboratory for Bioengineering and Sensing Technology, Daxing Research Institute, School of Chemistry & Biological Engineering, University of Science & Technology Beijing, Beijing 100083, China;Department of Orthopedics and Trauma, Peking University People’s Hospital, Beijing 100083, China;

关键词: peripheral nerve injury;    nerve conduits;    nerve reconstruction;    polymeric scaffold;    natural and synthetic polymers;   

DOI  :  10.3390/molecules26092712

来源: DOAJ

【 摘 要 】

The nervous system is a significant part of the human body, and peripheral nerve injury caused by trauma can cause various functional disorders. When the broken end defect is large and cannot be repaired by direct suture, small gap sutures of nerve conduits can effectively replace nerve transplantation and avoid the side effect of donor area disorders. There are many choices for nerve conduits, and natural materials and synthetic polymers have their advantages. Among them, the nerve scaffold should meet the requirements of good degradability, biocompatibility, promoting axon growth, supporting axon expansion and regeneration, and higher cell adhesion. Polymer biological scaffolds can change some shortcomings of raw materials by using electrospinning filling technology and surface modification technology to make them more suitable for nerve regeneration. Therefore, polymer scaffolds have a substantial prospect in the field of biomedicine in future. This paper reviews the application of nerve conduits in the field of repairing peripheral nerve injury, and we discuss the latest progress of materials and fabrication techniques of these polymer scaffolds.

【 授权许可】

Unknown