The Effect of Physical Exercise on Cognitive Impairment in Neurodegenerative Disease: From Pathophysiology to Clinical and Rehabilitative Aspects

International Journal of Molecular Sciences

Maria Vittoria Raele¹  Maurizio Ranieri¹  Giacomo Farì¹  Alessandra Cera¹  Giovanni Pignatelli¹  Marisa Megna¹  Giulia Mintrone¹  Loredana Capobianco²  Paola Lunetti² 

[1] Department of Basic Medical Sciences, Neurosciences and Sense Organs, Aldo Moro University, Piazza Umberto I, 70121 Bari, Italy;Department of Biological and Environmental Science and Technologies (Di.S.Te.B.A.), University of Salento, Piazza Tancredi 7, 73100 Lecce, Italy;

关键词: physical activity;    exercise;    rehabilitation;    Alzheimer’s disease;    Parkinson’s disease;   

DOI  :  10.3390/ijms222111632

来源: DOAJ

【 摘 要 】

Neurodegenerative diseases are a group of pathologies that cause severe disability due to motor and cognitive limitations. In particular, cognitive impairment is a growing health and socioeconomic problem which is still difficult to deal with today. As there are no pharmacologically effective treatments for cognitive deficits, scientific interest is growing regarding the possible impacts of healthy lifestyles on them. In this context, physical activity is gaining more and more evidence as a primary prevention intervention, a nonpharmacological therapy and a rehabilitation tool for improving cognitive functions in neurodegenerative diseases. In this descriptive overview we highlight the neurobiological effects of physical exercise, which is able to promote neuroplasticity and neuroprotection by acting at the cytokine and hormonal level, and the consequent positive clinical effects on patients suffering from cognitive impairment.

【 授权许可】

Unknown