期刊论文详细信息
Molecules
Insecticidal Activities of Chloramphenicol Derivatives Isolated from a Marine Alga-Derived Endophytic Fungus, Acremonium vitellinum, against the Cotton Bollworm, Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae)
Wei Li1  Zhao-Xia Li1  Dan Chen2  Feng-Long Wang2  Tong Liu3  Peng Zhang3  Xiu-Fang Wang3 
[1] College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China;College of Plant Protection, Shenyang Agricultural University, Shenyang 110866, China;Tobacco Research Institute of Chinese Academy of Agricultural Sciences (CAAS), Qingdao 266101, China;
关键词: alga-derived endophytic fungus;    Acremonium vitellinum;    secondary metabolites;    insecticidal activities;    molecular mechanism;   
DOI  :  10.3390/molecules23112995
来源: DOAJ
【 摘 要 】

A great deal of attention has been focused on the secondary metabolites produced by marine endophytic fungi, which can be better alternatives to chemicals, such as biopesticides, for control of polyphagous pests. On the basis of its novel biocontrol attributes, chemical investigation of a marine alga-derived endophytic fungus, Acremonium vitellinum, resulted in the isolation of three chloramphenicol derivatives (compounds 13). Their chemical structures were elucidated by detailed analysis of their nuclear magnetic resonance spectra, high-resolution electrospray ionization mass spectrometry, and by comparison with the data available in the literature. In this paper, compound 2 was firstly reported as the natural origin of these fungal secondary metabolites. The insecticidal activities of compounds 13 against the cotton bollworm, Helicoverpa armigera, were evaluated. The natural compound 2 presented considerable activity against H. armigera, with an LC50 value of 0.56 ± 0.03 mg/mL (compared to matrine with an LC50 value of 0.24 ± 0.01 mg/mL). Transcriptome sequencing was used to evaluate the molecular mechanism of the insecticidal activities. The results presented in this study should be useful for developing compound 2 as a novel, ecofriendly and safe biopesticide.

【 授权许可】

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