Synthesis, Larvicidal Activities and Antifungal Activities of Novel Chlorantraniliprole Derivatives and Their Target in the Ryanodine Receptor

Molecules

Qichao Chen¹  Lixia Xiong²  Min Luo¹  Jin Wang¹  Changyan Hu¹  Xiao Zhang²  Shujing Yu²  Yonghong Li²  Dequn Sun¹ 

[1] Marine College, Shandong University at Weihai, No. 180, Wenhua West Road, Weihai 264209, China; E-Mails:;State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China; E-Mails:

关键词: anthranilic diamides;    chlorantraniliprole;    ryanodine receptor;    insecticidal activities;    antifungal activities;    molecular docking;   

DOI  :  10.3390/molecules20033854

来源: mdpi

【 摘 要 】

In order to identify novel chlorantraniliprole derivatives as potential insecticides or fungicides, 25 analogues of chlorantraniliprole were synthesized. The insecticidal activities against oriental armyworm and the antifungal activities against five typical fungi of these derivatives were tested. Compounds 2u, 2x and 2y exhibited good activities against oriental armyworm, especially compounds 2u and 2x which showed higher larvicidal activities than indoxacarb. Moreover, all of the tested compounds exhibited activities against five typical fungi. The Ki values of all synthesized compounds were calculated using AutoDock4. The relationship between the Ki values and the results of insecticidal activities against oriental armyworm further indicated that the membrane-spanning domain protein of the ryanodine receptor might contain chlorantraniliprole binding sites.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.