Cooperation of cell adhesion and autophagy in the brain: Functional roles in development and neurodegenerative disease

Matrix Biology Plus

Andrea M. Reyes-Ortiz¹  Gianna Fote²  Joan S. Steffan³  Sarah J. Hernandez⁴  Leslie M. Thompson⁵ 

[1] Corresponding authors at: Neurobiology and Behavior, University of California Irvine, 845 Health Sciences Rd., Irvine, CA 92617, USA.;Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA 92697, USA;Department of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA;Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA;Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA 92697, USA;

关键词: Adhesion;    Autophagy;    Extracellular matrix;    Huntington’s disease;    Integrin;    Neurodegenerative disease;   

DOI  :  

来源: DOAJ

【 摘 要 】

Cellular adhesive connections directed by the extracellular matrix (ECM) and maintenance of cellular homeostasis by autophagy are seemingly disparate functions that are molecularly intertwined, each regulating the other. This is an emerging field in the brain where the interplay between adhesion and autophagy functions at the intersection of neuroprotection and neurodegeneration. The ECM and adhesion proteins regulate autophagic responses to direct protein clearance and guide regenerative programs that go awry in brain disorders. Concomitantly, autophagic flux acts to regulate adhesion dynamics to mediate neurite outgrowth and synaptic plasticity with functional disruption contributed by neurodegenerative disease. This review highlights the cooperative exchange between cellular adhesion and autophagy in the brain during health and disease. As the mechanistic alliance between adhesion and autophagy has been leveraged therapeutically for metastatic disease, understanding overlapping molecular functions that direct the interplay between adhesion and autophagy might uncover therapeutic strategies to correct or compensate for neurodegeneration.

【 授权许可】

Unknown