Severe invasive methicillin-resistant S. aureus (USA300 clone) infection in an Italian adolescent

Clinical Management Issues

Annalisa Pantosti¹  Francesca Crea²  Donatella Angelone³  Piero Valentini³ 

[1]Dipartimento di Malattie Infettive, Parassitarie e Immunomediate, Istituto Superiore di Sanità, Roma

[2]Divisione di Endocrinologia, Ospedale Pediatrico “Bambino Gesù”

[3]Istituto di Clinica Pediatrica, Università Cattolica del Sacro Cuore

关键词: MRSA;    Sepsis;    Meningitis;    Necrotizing pneumonia;    Antibiotic resistance;   

DOI  :  10.7175/cmi.v3i4.540

来源: DOAJ

【 摘 要 】

This report describes an uncommon presentation of invasive community-acquired methicillin-resistant S. aureus (CA-MRSA) infection in an immunocompetent adolescent without any other risk factor, characterized by septicaemia, meningitis, necrotising pneumonia and deep venous thrombosis (DVT). Successful treatment was performed with linezolid, rifampicin and low-molecular-weight heparin (LMWH). MRSA molecular typing revealed the presence of Panton-Valentine leukocidin (PVL) gene, and a genetic background identical to USA300 clone, an emerging aggressive CA-MRSA strain in USA and Europe.

【 授权许可】

Unknown