Is there a role for blood purification therapies targeting cytokine storm syndrome in critically severe COVID-19 patients?

Renal Failure

Yangzhong Zhou¹  Jie Ma²  Yan Qin²  Xuemei Li²  Gang Chen²  Peng Xia² 

[1] Department of Internal Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences;Nephrology Department, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences;

关键词: covid-19;    acute kidney injury;    cytokine storm;    blood purification;    oxiris;    cytosorb;   

DOI  :  10.1080/0886022X.2020.1764369

来源: DOAJ

【 摘 要 】

The coronavirus disease-19 (COVID-19) has spread over many countries and regions since the end of 2019, becoming the most severe public health event at present. Most of the critical cases developed multiple organ dysfunction, including acute kidney injury (AKI). Cytokine storm syndrome (CSS) may complicate the process of severe COVID-19 patients. This manuscript reviews the different aspects of blood purification in critically ill patients with AKI and increased inflammatory factors, and examines its potential role in severe COVID-19 treatment. Continuous renal replacement therapy (CRRT) has been practiced in many sepsis patients with AKI. Still, the timing and dosing need further robust evidence. In addition to the traditional CRRT, the high-throughput membrane with adsorption function and cytokine adsorption column are two representatives of recently emerging novel membrane technologies. Their potential in removing inflammatory factors and other toxins prospects for the treatment of severe COVID-19.

【 授权许可】

Unknown