Nonlinear Dynamical Model Based Control of in vitro Hippocampal Output

Frontiers in Neural Circuits

Theodore William Berger¹  Min-Chi eHsiao¹  Dong eSong¹ 

[1] University of Southern California;

关键词: Hippocampus;    Neural Prostheses;    Volterra kernel;    trajectory model;    inverse control;   

DOI  :  10.3389/fncir.2013.00020

来源: DOAJ

【 摘 要 】

This paper describes a modeling-control paradigm to control the hippocampal output (CA1 response) for the development of hippocampal prostheses.In order to bypass a damaged hippocampal region (e.g., CA3), downstream hippocampal signal (e.g., CA1 responses) needs to be reinstated based on the upstream hippocampal signal (e.g., dentate gyrus responses) via appropriate stimulations to the downstream (CA1) region.In this approach, we optimize the stimulation signal to CA1 by using a predictive DG-CA1 nonlinear model (i.e., DG-CA1 trajectory model) and an inversion of the CA1 input-output model (i.e., inverse CA1 plant model).The desired CA1 responses are first predicted by the DG-CA1 trajectory model and then used to derive the optimal stimulation intensity through the inverse CA1 plant model.Laguerre-Volterra kernel models for random-interval, graded-input, contemporaneous-graded-output system are formulated and applied to build the DG-CA1 trajectory model and the CA1 plant model.The inverse CA1 plant model to transform desired output to input stimulation is derived from the CA1 plant model.We validate this paradigm with rat hippocampal slice preparations.Results show that the CA1 responses evoked by the optimal stimulations accurately replicate the CA1 responses recorded in the hippocampal slice with intact trisynaptic pathway.

【 授权许可】

Unknown