Immunohistochemical Analysis of a Vitreous Membrane Removed from a Patient with Incontinentia Pigmenti-Related Retinal Detachment

Vision

György Benedek¹  Dóra Török²  Ágnes Jánossy³  András Hári Kovács³  Márta Janáky³  Béla Ivanyi⁴  Gábor Braunitzer⁵ 

[1] Cognition and Clinical Neuroscience, Nyírő Gyula Hospital, 1135 Budapest, Hungary;Department of Medical Genetics, University of Szeged, 6720 Szeged, Hungary;Department of Ophthalmology, University of Szeged, Koranyi fasor 4-8, H-6701 Szeged, Hungary;Department of Pathology, University of Szeged, 6720 Szeged, Hungary;;Laboratory for Perception &

关键词: incontinentia pigmenti;    epiretinal membrane;    immunohistochemistry;    hereditary diseases;   

DOI  :  10.3390/vision4010005

来源: DOAJ

【 摘 要 】

This is a case history of a 23-year-old woman suffering from incontinentia pigmenti (IP). The patient’s vision in the left eye started to deteriorate due to cataract progression at the age of 22, and by the age of 23, it dropped from 0.9 to 0.04. Ultrasound examination confirmed tractional vitreoretinal membranes. Vitrectomy was performed, therefore, on her left eye. The histological evaluation of vitreous membrane revealed a complex immunophenotype (positivity for glial fibrillary acidic protein (GFAP), vimentin, S-100, anti-pan cytokeratin antibody (AE/AE3), and smooth muscle-specific actin (SMA) to various extents). The right eye remained unsymptomatic throughout this course. Besides being the first to analyze the tractional vitreoretinal membrane in IP with immunohistochemical methods, this case study points out that extreme cases of asymmetric side involvement in IP do exist, even to the point of one eye being completely unsymptomatic.

【 授权许可】

Unknown