Evaluation of edaravone against radiation-induced oral mucositis in mice

Journal of Pharmacological Sciences

Noriko Nakajima¹  Shinichi Watanabe²  Akihiro Tanaka²  Hiroaki Araki²  Takeshi Kiyoi³  Katsuya Suemaru⁴ 

[1] Department of Clinical Pharmacy, Graduate School of Medicine, Ehime University, 454 Shitsukawa, Toon, Ehime 791-0295, Japan;Division of Pharmacy, Ehime University Hospital, 454 Shitsukawa, Toon, Ehime 791-0295, Japan;Integrated Center for Science, Ehime University, 454 Shitsukawa, Toon, Ehime 791-0295, Japan;School of Pharmacy, Shujitsu University, 1-6-1 Nishigawara, Okayama 703-8516, Japan;

关键词: Antioxidant effect;    Edaravone;    Mouse;    Oral mucositis;    Radiation;   

DOI  :  10.1016/j.jphs.2015.02.001

来源: DOAJ

【 摘 要 】

Oral mucositis induced by radiotherapy for cancers of the head and neck reduce the quality of life of patients. However, effective therapeutic agents are lacking. Symptomatic treatment involves local anesthesia and analgesia. We focused on the antioxidant effects of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one; Radicut®). Oral mucositis was induced on the tongue tips of mice using a single dose of X-rays (20 Gy). To evaluate the protective effect of edaravone (30 and 300 mg/kg), administration was carried out 30 min before irradiation. Survival, oral mucositis score, myeloperoxidase activity, and levels of 2-Thiobarbituric acid reactive substances were measured, and all were improved compared with those of control mice. A significant difference was not found in terms of survival due to edaravone. Histopathologic findings also highlighted the beneficial features of edaravone. Edaravone reduced the production of reactive oxygen species. These findings suggest that the protective effect of edaravone against radiation-induced oral mucositis is through an antioxidant effect.

【 授权许可】

Unknown