Long Non-coding RNA RMRP in the Pathogenesis of Human Disorders

Frontiers in Cell and Developmental Biology

Hazha Jamal Hidayat¹  Tahereh Azimi²  Soudeh Ghafouri-Fard²  Bashdar Mahmud Hussen³  Mohammad Taheri⁴ 

[1] Department of Biology, College of Education, Salahadddin University-Erbil, Erbil, Iraq;Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq;Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: long non-coding RNA RMRP;    cancer;    expression;    biomarkers;    cell lines;   

DOI  :  10.3389/fcell.2021.676588

来源: DOAJ

【 摘 要 】

RNA component of mitochondrial RNA processing endoribonuclease (RMRP) is a non-coding transcript firstly acknowledged for its association with the cartilage-hair hypoplasia (CHH) syndrome, a rare autosomal recessive condition. This transcript has been spotted in both nucleus and mitochondria. In addition to its role in the pathogenesis of CHH, RMRP participates in the pathogenesis of cancers. Independent studies in bladder cancer, colon cancer, hepatocellular carcinoma, lung cancer, breast carcinoma and multiple myeloma have confirmed the oncogenic effects of RMRP. Mechanistically, RMRP serves as a sponge for some miRNAs such as miR-206, miR-613, and miR-217. In addition to these miRNAs, expressions of tens of miRNAs have been altered following RMRP silencing, implying the vast extent of RMRP/miRNA network. In the present narrative review, we explain the role of RMRP in the development of cancers and some other non-malignant disorders.

【 授权许可】

Unknown