The Emerging Role of Long Non-coding RNAs and Circular RNAs in Coronary Artery Disease

Frontiers in Cardiovascular Medicine

Mahdi Gholipour¹  Soudeh Ghafouri-Fard²  Mohammad Taheri³ 

[1] Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

关键词: long non-coding RNA;    circRNA;    coronary artery disorder;    expression;    biomarkers;   

DOI  :  10.3389/fcvm.2021.632393

来源: Frontiers

【 摘 要 】

Coronary artery disease (CAD) is a common disorder caused by atherosclerotic processes in the coronary arteries. This condition results from abnormal interactions between numerous cell types in the artery walls. The main participating factors in this process are accumulation of lipid deposits, endothelial cell dysfunction, macrophage induction, and changes in smooth muscle cells. Several lines of evidence underscore participation of long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in the pathogenesis of CAD. Several lncRNAs such as H19, ANRIL, MIAT, lnc-DC, IFNG-AS1, and LEF1-AS1 have been shown to be up-regulated in the biological materials obtained from CAD patients. On the other hand, Gas5, Chast, HULC, DICER1-AS1, and MEG3 have been down-regulated in CAD patients. Meanwhile, a number of circRNAs have been demonstrated to influence function of endothelial cells or vascular smooth muscle cells, thus contributing to the pathogenesis of CAD. In the current review, we summarize the function of lncRNAs and circRNAs in the development and progression of CAD.

【 授权许可】

CC BY