Platinum nanoparticles: an exquisite tool to overcome radioresistance

Cancer Nanotechnology

Murielle Dutertre¹  Fabrice Confalonieri¹  Hynd Remita²  Erika Porcel³  Sha Li³  Sandrine Lacombe³  Sergio Marco⁴  Matthieu Réfrégiers⁵ 

[1] CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Univ. Paris-Sud, Université Paris Saclay;CNRS, UMR 8000, Laboratoire de Chimie Physique, Université Paris-Sud;CNRS, UMR 8214, Institut des Sciences Moléculaires d’Orsay, Université Paris Sud;Institut Curie/INSERM U759, Campus Universitaire d’Orsay;Synchrotron SOLEIL;

关键词: Metallic nanoparticles;    Radioresistance;    Radio-enhancement;    Radiosensitization;    Deinococcus radiodurans;   

DOI  :  10.1186/s12645-017-0028-y

来源: DOAJ

【 摘 要 】

Abstract Backgroud Small metallic nanoparticles are proposed as potential nanodrugs to optimize the performances of radiotherapy. This strategy, based on the enrichment of tumours with nanoparticles to amplify radiation effects in the tumour, aims at increasing the cytopathic effect in tumours while healthy tissue is preserved, an important challenge in radiotherapy. Another major cause of radiotherapy failure is the radioresistance of certain cancers. Surprisingly, the use of nanoparticles to overcome radioresistance has not, to the best of our knowledge, been extensively investigated. The mechanisms of radioresistance have been extensively studied using Deinococcus radiodurans, the most radioresistant organism ever reported, as a model. Methods In this work, we investigated the impact of ultra-small platinum nanoparticles (1.7 nm) on this organism, including uptake, toxicity, and effects on radiation responses. Results We showed that the nanoparticles penetrate D. radiodurans cells, despite the 150 nm cell wall thickness with a minimal inhibition concentration on the order of 4.8 mg L−1. We also found that the nanoparticles amplify gamma ray radiation effects by >40%. Conclusions Finally, this study demonstrates the capacity of metallic nanoparticles to amplify radiation in radioresistant organisms, thus opening the perspective to use nanoparticles not only to improve tumour targeting but also to overcome radioresistance.

【 授权许可】

Unknown