Benzenetriol-Derived Compounds against Citrus Canker

Molecules

PeterJ. Deuss¹  CiaranW. Lahive¹  Fleur Gijsbers²  Dirk-Jan Scheffers²  LúciaBonci Cavalca²  FernandoRogério Pavan³ 

[1] Department of Chemical Engineering (ENTEG), University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands;Department of Molecular Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, The Netherlands;School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, Brazil;

关键词: Xanthomonas citri;    antimicrobials;    lignocellulosic biomass;    bio-based chemicals;    phenolic compounds;   

DOI  :  10.3390/molecules26051436

来源: DOAJ

【 摘 要 】

In order to replace the huge amounts of copper salts used in citrus orchards, alternatives have been sought in the form of organic compounds of natural origin with activity against the causative agent of citrus canker, the phytopathogen Xanthomonas citri subsp. Citri. We synthesized a series of 4-alkoxy-1,2-benzene diols (alkyl-BDOs) using 1,2,4-benzenetriol (BTO) as a starting material through a three-step synthesis route and evaluated their suitability as antibacterial compounds. Our results show that alkyl ethers derived from 1,2,4-benzenetriol have bactericidal activity against X. citri, disrupting the bacterial cell membrane within 15 min. Alkyl-BDOs were also shown to remain active against the bacteria while in solution, and presented low toxicity to (human) MRC-5 cells. Therefore, we have demonstrated that 1,2,4-benzenetriol—a molecule that can be obtained from agricultural residues—is an adequate precursor for the synthesis of new compounds with activity against X. citri.

【 授权许可】

Unknown