Innovative Bio-Based Organic UV-A and Blue Light Filters from Meldrum’s Acid

Molecules

Patrick Balaguer¹  Fanny Brunissen²  Cédric Peyrot²  MatthieuM. Mention²  Florent Allais² 

[1] IRCM, Inserm, Univ Montpellier, ICM, 208 Avenue des Apothicaires, CEDEX 5, 34298 Montpellier, France;URD Agro-Biotechnologies Industrielles (ABI), CEBB, AgroParisTech, 51110 Pomacle, France;

关键词: photoprotection;    bio-based chemicals;    Meldrum’s acid;    UV-A;    blue light;    organic UV filters;   

DOI  :  10.3390/molecules25092178

来源: DOAJ

【 摘 要 】

Faced with the ban of some organic UV filters such as octinoxate or avobenzone, especially in Hawaii, it became essential to offer new alternatives that are both renewable and safe for humans and the environment. In this context, a class of bio-based molecules displaying interesting UV filter properties and great (photo)stability has been developed from Meldrum’s acid and bio-based and synthetic p-hydroxycinnamic acids, furans and pyrroles. Moreover, p-hydroxycinnamic acid-based Meldrum’s derivatives possess valuable secondary activities sought by the cosmetic industry such as antioxidant and anti-tyrosinase properties. The evaluation of the properties of mixture of judiciously chosen Meldrum’s acid derivatives highlighted the possibility to modulate secondary activity while maintaining excellent UV protection. Meldrum’s acid derivatives are not only competitive when benchmarked against organic filters currently on the market (i.e., avobenzone), but they also do not exhibit any endocrine disruption activity.

【 授权许可】

Unknown