Palladium-Catalyzed Dehydrogenative Coupling: An Efficient Synthetic Strategy for the Construction of the Quinoline Core

Marine Drugs

Asier Carral-Menoyo¹  Verónica Ortiz-de-Elguea¹  Nuria Sotomayor¹  Esther Lete¹  Mikel Martinez-Nunes¹ 

[1] Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco/Euskal Herriko Unibertsitatea UPV/EHU, Apdo. 644, 48080 Bilbao, Spain;

关键词: quinoline;    synthesis;    palladium;    coupling;    C–H alkenylation;   

DOI  :  10.3390/md15090276

来源: DOAJ

【 摘 要 】

Palladium-catalyzed dehydrogenative coupling is an efficient synthetic strategy for the construction of quinoline scaffolds, a privileged structure and prevalent motif in many natural and biologically active products, in particular in marine alkaloids. Thus, quinolines and 1,2-dihydroquinolines can be selectively obtained in moderate-to-good yields via intramolecular C–H alkenylation reactions, by choosing the reaction conditions. This methodology provides a direct method for the construction of this type of quinoline through an efficient and atom economical procedure, and constitutes significant advance over the existing procedures that require preactivated reaction partners.

【 授权许可】

Unknown