Pd/C-mediated dual C-C bond forming reaction in water: synthesis of 2,4-dialkynylquinoline

Journal of the Brazilian Chemical Society

Reddy, Ellanki A¹  JNT University, Hyderabad, India¹  Matrix Laboratories Ltd, Medak District, India¹  Pal, Manojit¹  Venu, Bolla K¹  Mukkanti, K¹  Dr. Reddy's Laboratories Limited, Hyderabad, India¹  Islam, Aminul¹ 

关键词: quinoline;    palladium;    charcoal;    copper;    C-C bond;    alkyne;   

DOI  :  10.1590/S0103-50532010000900012

学科分类：化学（综合）

来源: SciELO

【 摘 要 】

Pd/C facilitated dual C-C bond forming reaction between 2,4-diiodoquinoline and terminal alkynes in water providing a practical and one-step synthesis of 2,4-dialkynylquinolines. A number of related quinoline derivatives were prepared in good to excellent yields using this water-based methodology. The use of other palladium catalysts and solvents was examined and the mechanism of the reaction has been discussed.

【 授权许可】

Unknown