Assessment of the Cytoprotective Efficacy of Amifostine with Quantitative Salivary Gland Scintigraphy

Dicle Medical Journal

关键词: Amifostine;    Cytoprotection;    Radionuclide Imaging;    Salivary Glands;   

DOI  :  

来源: DOAJ

【 摘 要 】

The main objective of our study was to assess and confirm the radioprotective effect of amifostine in protecting major salivary glands with dynamic quantitative scintigraphic evaluation.The study design was non-randomized clinical trial. There were 26 patients with head and neck cancer who receive primary or adjuvant radiotherapy in the head and neck region. Amifostine administrations were done before radiotherapy in one group while the control group did not take the drug. The primary end-point was wash-out rate as the quantitative scintigraphic parameter and changing patterns after radiotherapy were compared. Parotid wash-out rate showed some healing at the 3rd month of radiotherapy in the amifostine group, but not in the control group. Submandibular wash-out rate showed some worsening at the 3rd month of radiotherapy in the control group, but not in the amifostine group. Radioprotective effect of amifostine in major salivary glands can be observed with the testing tool of dynamic quantitative salivary gland scintigraphy.

【 授权许可】

Unknown