Comparison of salivary epidermal growth factor levels in patients with gingivitis and advanced periodontitis and healthy subjects.

Frontiers in Dentistry

卷:11

Siamak Yaghoobee¹  Amir Alireza Rasouli Ghahroudi¹  Mahvash Moosavijazi¹  Eisa Salehi²  Mojtaba Bayani³  Roozbeh Sadrimanesh⁴ 

[1] Assistant Professor, Dental Research Center Dentistry Research Institute Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.;

[2] Assistant Professor, Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.;

[3] Postgraduate Student, Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.;

[4] Prosthodontist, Private Practice, Tehran, Iran.;

关键词: Epidermal Growth Factor;    Gingivitis;    Periodontitis;    Salivary Glands;    Salivary Proteins and Peptides;   

DOI  :  

来源: DOAJ

【 摘 要 】

Epidermal growth factor (EGF) is a polypeptide molecule, with important functions in epithelial growth and wound repair. It exerts its effects on cells by binding to receptors on the cell surface. The aim of this study was to evaluate and compare salivary EGF levels in patients with gingivitis and advanced periodontitis as well as in healthy controls.Unstimulated salivary samples were collected from patients with gingivitis and advanced periodontitis and healthy individuals. The clinical parameters of plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL) were measured and recorded using a Williams probe. The enzyme-linked immunosorbent assay (ELISA) was used to determine salivary levels of EGF. One-way ANOVA was used for data analysis.The mean salivary level of EGF in healthy individuals (99.27) was significantly higher than that in patients with gingivitis (61.53). This value in patients with gingivitis (61.53) was also significantly higher than that in subjects with periodontitis (36.14) (P

【 授权许可】

Unknown