Interleukin Receptor Associated Kinase 1 Signaling and Its Association with Cardiovascular Diseases

Reviews in Cardiovascular Medicine

Youjing Zheng¹  Jia-Qiang He¹ 

[1] Department of Biomedical Sciences and Pathobiology, College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA;

关键词: interleukin-1 receptor associated kinase 1;    innate immune response;    signaling pathways;    toll-like receptor;    interleukin-1 receptor;    endothelial cells;    vascular smooth muscle cells;    cardiomyocytes;    atherosclerosis;    myocardial infarction;    heart failure;   

DOI  :  10.31083/j.rcm2303097

来源: DOAJ

【 摘 要 】

Toll-like receptors (TLRs) and interleukin-1 receptor (IL-1R) directly interact with intracellular interleukin receptor associated kinase (IRAK) family members to initialize innate immune and inflammatory responses following activation by pathogen-associated or host-derived elements. Although four IRAK family members [IRAK1, 2, 3 (i.e., IRAK-M), and 4] are involved in TLR and IL-1R signaling pathways, IL-1R > IRAK1 signaling appears to be the most studied pathway, with sufficient evidence to support its central role linking the innate immune response to the pathogenesis of various diseases, including cancers, metabolic disorders, and non-infectious immune disorders. However, IRAK1’s involvement in cardiovascular diseases was only recently revealed and the detailed mechanism underling the pathogenesis of cardiovascular diseases, such as atherosclerosis, myocardial infarction, and heart failure (all non-infectious disorders), remains largely unknown with very limited publications to date. This review aims to summarize the overall roles of the IRAK family, especially IRAK1, in mediating the development of cardiovascular diseases.

【 授权许可】

Unknown