The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review

International Journal of Molecular Sciences

Xuanbin Wang²  Longchao Xiang²  Hongliang Li²  Ping Chen²  Yibin Feng¹  Jingxuan Zhang²  Nian Yang²  Fei Li²  Ye Wang²  Quifang Zhang²  Fang Li²  Fengjun Cao² 

[1] School of Chinese Medicine, the University of Hong Kong, 10 Sassoon Road, Pokfulam, Hong Kong, China; E-Mail:;Laboratory of Chinese Herbal Pharmacology, Renmin Hospital, 30 South Renmin Road, Shiyan 442000, Hubei, China; E-Mails:

关键词: high mobility group protein B1;    receptor for advanced glycation end product;    toll-like receptor;    triggering receptor expressed on myeloid cells-1;    hepatocellular carcinoma;   

DOI  :  10.3390/ijms160922527

来源: mdpi

【 摘 要 】

The story of high mobility group protein B1 (HMGB1) in cancer is complicated and the function of HMGB1 in different cancers is uncertain. This review aims to retrieve literature regarding HMGB1 from English electronic resources, analyze and summarize the role of the HMGB1 signaling pathway in hepatocellular carcinoma (HCC), and provide useful information for carcinogenesis and progression of HCC. Results showed that HMGB1 could induce cell proliferation, differentiation, cell death, angiogenesis, metastasis, inflammation, and enhance immunofunction in in vitro and in vivo HCC models. HMGB1 and its downstream receptors RAGE, TLRs and TREM-1 may be potential anticancer targets. In conclusion, HMGB1 plays an important role in oncogenesis and represents a novel therapeutic target, which deserves further study.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.