Iron Oxide Mediated Photothermal Therapy in the Second Biological Window: A Comparative Study between Magnetite/Maghemite Nanospheres and Nanoflowers

Nanomaterials

Alberto Curcio¹  Claire Wilhelm¹  Sonia Cabana²  Aude Michel²  Ali Abou-Hassan² 

[1] Laboratoire Matière et Systèmes Complexes, CNRS UMR 7057, Université de Paris, 10 rue Alice Domon et Léonie Duquet, 75205 Paris CEDEX 13, France;Laboratoire de PHysico-chimie des Électrolytes et Nanosystèmes InterfaciauX (PHENIX), CNRS UMR8234, Sorbonne Université, F-75252 Paris CEDEX 05, France;

关键词: magnetic nanoparticles;    second biological window;    photothermia;    nanothermal therapies;    magnetic nanoflowers;   

DOI  :  10.3390/nano10081548

来源: DOAJ

【 摘 要 】

The photothermal use of iron oxide magnetic nanoparticles (NPs) is becoming more and more popular and documented. Herein, we compared the photothermal (PT) therapy potential versus magnetic hyperthermia (MHT) modality of magnetic nanospheres, largely used in the biomedical field and magnetic multicore nanoflowers known among the best nanoheaters. The NPs were imaged using transmission electron microscopy and their optical properties characterized by UV-Vis-NIR-I-II before oxidation (magnetite) and after oxidation to maghemite. The efficiency of all NPs in MHT and PT in the preferred second near-infrared (NIR-II) biological window was carried out in water and in cancer cells. We show that, in water, magnetite nanoflowers are the most efficient nanoheaters for both modalities. Moreover, PT appears much more efficient than MHT at low NP dose, whatever the NP. In the cellular environment, for PT, efficiency was totally conserved, with magnetite nanoflowers as the best performers compared to MHT, which was totally lost. Finally, cell uptake was significantly increased for the nanoflowers compared to the nanospheres. Finally, the antitumor therapy was investigated for all NPs at the same dose delivered to the cancer cells and at reasonable laser power density (0.3 W/cm²), which showed almost total cell death for magnetite nanoflowers.

【 授权许可】

Unknown