Magnetite Nanostructures as Novel Strategies for Anti-Infectious Therapy

Molecules

Ioannis Liakos²  Alexandru Mihai Grumezescu¹ 

[1] Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1-7, Bucharest 011061, Romania;Nanophysics Department, Istituto Italiano di Tecnologia (IIT), via Morego 30, Genova 16163, Italy

关键词: infectious diseases;    antimicrobials;    antibiotics;    magnetic nanoparticles;    drug delivery;   

DOI  :  10.3390/molecules190812710

来源: mdpi

【 摘 要 】

This review highlights the current situation of antimicrobial resistance and the use of magnetic nanoparticles (MNPs) in developing novel routes for fighting infectious diseases. The most important two directions developed recently are: (i) improved delivery of antimicrobial compounds based on a drastic decrease of the minimal inhibition concentration (MIC) of the drug used independently; and (ii) inhibition of microbial attachment and biofilm development on coated medical surfaces. These new directions represent promising alternatives in the development of new strategies to eradicate and prevent microbial infections that involve resistant and biofilm-embedded bacteria. Recent promising applications of MNPs, as the development of delivery nanocarriers and improved nanovehicles for the therapy of different diseases are discussed, together with the mechanisms of microbial inhibition.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.