New Insights into Cellular Functions of Nuclear Actin

Biology

JacekZ. Kubiak¹  Ahmed Uosef²  Priyanka Chanana²  Malgorzata Kloc²  RafikM. Ghobrial²  Nicole Vaughn² 

[1] Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology (WIHE), 01-163 Warsaw, Poland;The Houston Methodist Research Institute, Houston, TX 77030, USA;

关键词: nuclear actin;    nuclear architecture;    intranuclear rods;    RhoA;    F actin;    G actin;   

DOI  :  10.3390/biology10040304

来源: DOAJ

【 摘 要 】

Actin is one of the most abundant proteins in eukaryotic cells. There are different pools of nuclear actin often undetectable by conventional staining and commercial antibodies used to identify cytoplasmic actin. With the development of more sophisticated imaging and analytical techniques, it became clear that nuclear actin plays a crucial role in shaping the chromatin, genomic, and epigenetic landscape, transcriptional regulation, and DNA repair. This multifaceted role of nuclear actin is not only important for the function of the individual cell but also for the establishment of cell fate, and tissue and organ differentiation during development. Moreover, the changes in the nuclear, chromatin, and genomic architecture are preamble to various diseases. Here, we discuss some of the newly described functions of nuclear actin.

【 授权许可】

Unknown