Actin—Towards a Deeper Understanding of the Relationship Between Tissue Context, Cellular Function and Tumorigenesis

Cancers

关键词: extracellular matrix;    laminin;    nuclear actin;    breast cancer;    epithelial;   

DOI  :  10.3390/cancers3044269

来源: mdpi

【 摘 要 】

It is well-established that the actin cytoskeleton plays an important role in tumor development yet the contribution made by nuclear actin is ill-defined. In a recent study, nuclear actin was identified as a key mediator through which laminin type III (LN1) acts to control epithelial cell growth. In the breast, epithelial tumors are surrounded by an environment which lacks LN1. These findings point to actin as a potential mediator of tumor development. Here our current understanding of the roles of cytoplasmic and nuclear actin in normal and tumor cell growth is reviewed, relating these functions to cell phenotype in a tissue context.

【 授权许可】

CC BY   
© 2011 by the authors; licensee MDPI, Basel, Switzerland.