Age-dependent changes in plasma amino acids contribute to alterations in glycoxidation products

Journal of Medical Biochemistry

Kheirouri Sorayya¹  Foroumandi Elaheh¹  Alizadeh Mohammad² 

[1] Tabriz University of Medical Sciences, Faculty of Nutrition, Department of Nutrition, Tabriz, Iran;Tabriz University of Medical Sciences, Nutrition Research Center, Tabriz, Iran;

关键词: advanced glycation end product;    amino acid;    aging;    glycation;    healthy;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Glycative stress is involved in the pathogenesis of various degenerative disorders. This study sought to determine the effect of age-related changes in amino acids on serum levels of pentosidine and carboxymethyl-lysine (CML) in healthy individuals. Methods: The subjects were 78 healthy individuals categorized into three age groups. The ages of the groups were as follows: 26 young adults (20-30 y, 25 .2± 3.03), 26 middle-aged adults (35-50 y, 39 .46 ± 6.97 ) and 26 older adults (60 y or older, 69.80± 10.01). Serum levels of pentosidine and CML were measured by ELISA and levels of plasma amino acids were determined using HPLC. Results: Serum levels of pentosidine and CML in the youngest group were higher than in the oldest group (p =0.026, 0.029, respectively). There was a positive correlation between the serum levels of pentosidine and CML and the levels of plasma Tyrosine (p =0.032, r=0.211 and p =0.037, r=0.224), Valine (p =0.037, r=0.224 and p = 0.021, r=0.247) and Isoleucine (p = 0.041, r=0.203 and p =0.021, r=0.247), respectively. Serum levels of pentosidine and CML may be modulated by the plasma levels of selected amino acids. Conclusions: Better understanding of the role of these selective amino acids might provide new perception of how glycation pathways may be altered and pave the way for new therapeutic principles.

【 授权许可】

Unknown